Direction of the heterocyclization reaction of 3-allyl- and 3-propargyl-sulfanyl-5H-[1,2,4]triazino[5,6-b]indoles

Abstract

It has been established by X-ray structural analysis that the iodocyclization of 3-allylsulfanyl-5H-[1,2,4]triazino[5,6-b]indole occurs at the N-2 atom. It was shown that heterocyclization of 3-propargylsulfanyl-5H-[1,2,4] triazino[5,6-b]indoles proceeds in the presence of alkali at the N-2 atom but under the action of sulfuric acid at the N-4 atom. © 2013 Springer Science+Business Media New York.