Modulatory influence of rarely repeated immobilization episodes on the interleukin-1β-dependent reaction of blood leukocytes and hepatoprotective effect of restraint stress

Abstract

Repeated episodes of 1-h restraint stress were accompanied by a decrease in the sensitivity of blood leukocytes and cytochrome P450-dependent monooxygenases of the liver to recombinant IL-1β. These changes are associated with the anti-inflammatory hepatoprotective effect of chronic stress. © 2011 Springer Science+Business Media, Inc.